Darius Butler returned an interception for a score as the Colts (6-3) won their fourth consecutive game and snapped a three-game losing streak in the series. The Jaguars (1-8) have lost six straight.
The Colts had cause for concern following an emotional victory four days earlier, one in which cancer-stricken coach Chuck Pagano delivered a passionate, postgame speech in the locker room. Interim coach Bruce Arians was worried the team might crash from the emotional high.
Not even close.
Indianapolis scored on three consecutive possessions in the first half, opening a 17-0 lead that started emptying the stands at EverBank Field.